癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AKR1B10 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant AKR1B10.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O60218 |
| Other Accession | NM_020299 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1A6 |
| Calculated MW | 36020 Da |
| Gene ID | 57016 |
|---|---|
| Other Names | Aldo-keto reductase family 1 member B10, 111-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11 |
| Target/Specificity | AKR1B10 (NP_064695, 76 a.a. ~ 143 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | AKR1B10 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
REFERENCES
1.Aldo-Ketoreductase Family 1 B10 (AKR1B10) as A Biomarker to Distinguish Hepatocellular Carcinoma from Benign Liver Lesions.Matkowskyj KA, Bai H, Liao J, Zhang W, Li H, Rao S, Omary R, Yang GY.Human Pathology(2013) Volume 45, Issue 4, April 2014, Pages 834–8432.An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern C, Wardle FC, Flanagan AM.J Pathol. 2012 Jul 30. doi: 10.1002/path.4082.3.A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.Moriguchi H, Zhang Y, Mihara M, Sato C.Sci Rep. 2012;2:280. Epub 2012 Feb 21.4.Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.Chung YT, Matkowskyj KA, Li H, Bai H, Zhang W, Tsao MS, Liao J, Yang GY.Mod Pathol. 2012 Jan 6. doi: 10.1038/modpathol.2011.191. [Epub ahead of print]5.AKR1B10 expression is associated with less aggressive hepatocellular carcinoma: a clinicopathological study of 168 cases.Schmitz KJ, Sotiropoulos GC, Baba HA, Schmid KW, Muller D, Paul A, Auer T, Gamerith G, Loeffler-Ragg J.Liver International DOI:10.1111/ j.1478-3231.2011. 02511.x6.Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.Bains OS, Grigliatti TA, Reid RE, Riggs KW.J Pharmacol Exp Ther. 2010 Sep 13. [Epub ahead of print]7.Combined functional genome survey of therapeutic targets for hepatocellular carcinoma.Satow R, Shitashige M, Kanai Y, Takeshita F, Ojima H, Jigami T, Honda K, Kosuge T, Ochiya T, Hirohashi S, Yamada T.Clin Cancer Res. 2010 May 1;16(9):2518-28. Epub 2010 Apr 13.8.Proteomic Analysis of Bronchoalveolar Lavage Fluid Obtained from Rats Exposed to Formaldehyde.Ahn KH, Kim SK, Lee JM, Jeon HJ, Lee DH, Kim DK.JOURNAL OF HEALTH SCIENCE Vol. 56 (2010) , No. 3 287-295
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