癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ALDH3A1 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a full length recombinant ALDH3A1.
- 产品详情
- 实验流程
- 背景知识
Application 
| IP, E |
|---|---|
| Primary Accession | P30838 |
| Other Accession | BC004370 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2G4 |
| Calculated MW | 50395 Da |
| Gene ID | 218 |
|---|---|
| Other Names | Aldehyde dehydrogenase, dimeric NADP-preferring, ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1, ALDH3A1, ALDH3 |
| Target/Specificity | ALDH3A1 (AAH04370, 1 a.a. ~ 453 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ALDH3A1 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. Nielsen SS, et al. Environ Health Perspect, 2010 Jan. PMID 20056567.The oxidation status of ALDH3A1 in human saliva and its correlation with antioxidant capacity measured by ORAC method. Bogucka M, et al. Acta Pol Pharm, 2009 Sep-Oct. PMID 19894643.Association study of genetic polymorphism in ABCC4 with cyclophosphamide-induced adverse drug reactions in breast cancer patients. Low SK, et al. J Hum Genet, 2009 Oct. PMID 19696793.
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