癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARRB2 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant ARRB2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P32121 |
| Other Accession | BC007427 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4D2 |
| Calculated MW | 46106 Da |
| Gene ID | 409 |
|---|---|
| Other Names | Beta-arrestin-2, Arrestin beta-2, ARRB2, ARB2, ARR2 |
| Target/Specificity | ARRB2 (AAH07427, 300 a.a. ~ 409 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ARRB2 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
REFERENCES
beta-Arrestin2 influences the response to methadone in opioid-dependent patients. Oneda B, et al. Pharmacogenomics J, 2010 Jun 1. PMID 20514076.Beta-arrestin 2 regulates Toll-like receptor 4-mediated apoptotic signalling through glycogen synthase kinase-3beta. Li H, et al. Immunology, 2010 Aug. PMID 20497256.Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence. Bousman CA, et al. Psychiatry Res, 2010 Jul 30. PMID 20478633.Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase. Kuhr FK, et al. FASEB J, 2010 Jul. PMID 20228252.Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. Shankar H, et al. J Biol Chem, 2010 Mar 12. PMID 20056609.
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