癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BOLL Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant BOLL.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q8N9W6 |
| Other Accession | NM_033030 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3E11 |
| Calculated MW | 31301 Da |
| Gene ID | 66037 |
|---|---|
| Other Names | Protein boule-like, BOLL, BOULE |
| Target/Specificity | BOLL (NP_149019, 185 a.a. ~ 283 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | BOLL Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
REFERENCES
Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. Kee K, et al. Nature, 2009 Nov 12. PMID 19865085.Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis. Lin YM, et al. J Clin Endocrinol Metab, 2009 Jul. PMID 19417033.Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population. Chen P, et al. J Androl, 2010 Mar-Apr. PMID 19342699.Susceptibility loci for intracranial aneurysm in European and Japanese populations. Bilguvar K, et al. Nat Genet, 2008 Dec. PMID 18997786.Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men. Kostova E, et al. Mol Hum Reprod, 2007 Feb. PMID 17114206.
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