癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CACNA1I Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant CACNA1I.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P0X4 |
| Other Accession | NM_021096 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3H5 |
| Calculated MW | 245103 Da |
| Gene ID | 8911 |
|---|---|
| Other Names | Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav33, Ca(v)33, CACNA1I, KIAA1120 |
| Target/Specificity | CACNA1I (NP_066919, 233 a.a. ~ 331 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CACNA1I Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Voltage-dependent calcium channels control the rapid entry of Ca(2+) into a variety of cell types and are therefore involved in both electrical and cellular signaling. T-type channels, such as CACNA1I, are activated by small membrane depolarizations and can generate burst firing and pacemaker activity.
REFERENCES
Differential interactions of Na+ channel toxins with T-type Ca2+ channels. Sun H, et al. J Gen Physiol, 2008 Jul. PMID 18591418.Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors. Hildebrand ME, et al. J Biol Chem, 2007 Jul 20. PMID 17535809.CACNA1I is not associated with childhood absence epilepsy in the Chinese Han population. Wang J, et al. Pediatr Neurol, 2006 Sep. PMID 16939858.Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. Zhang D, et al. J Biol Chem, 2006 Aug 4. PMID 16740636.International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Catterall WA, et al. Pharmacol Rev, 2005 Dec. PMID 16382099.
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