癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CACNA1S Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CACNA1S.
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Application 
| E |
|---|---|
| Primary Accession | Q13698 |
| Other Accession | NM_000069 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2C5 |
| Calculated MW | 212350 Da |
| Gene ID | 779 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit alpha-1S, Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Voltage-gated calcium channel subunit alpha Cav11, CACNA1S, CACH1, CACN1, CACNL1A3 |
| Target/Specificity | CACNA1S (NP_000060, 1743 a.a. ~ 1838 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CACNA1S Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.
REFERENCES
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The role of CACNA1S in predisposition to malignant hyperthermia. Carpenter D, et al. BMC Med Genet, 2009 Oct 13. PMID 19825159.Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a South American family. Ke T, et al. J Hum Genet, 2009 Nov. PMID 19779499.Increasing the number of diagnostic mutations in malignant hyperthermia. Levano S, et al. Hum Mutat, 2009 Apr. PMID 19191329.
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