癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CENPA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CENPA.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P49450 |
| Other Accession | BC000881 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1D4-1A3 |
| Calculated MW | 15991 Da |
| Gene ID | 1058 |
|---|---|
| Other Names | Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA |
| Target/Specificity | CENPA (AAH00881, 1 a.a. ~ 114 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CENPA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
REFERENCES
Dual recognition of CENP-A nucleosomes is required for centromere assembly. Carroll CW, et al. J Cell Biol, 2010 Jun 28. PMID 20566683.Molecular and evolutionary characteristics of the fraction of human alpha satellite DNA associated with CENP-A at the centromeres of chromosomes 1, 5, 19, and 21. Pironon N, et al. BMC Genomics, 2010 Mar 23. PMID 20331851.Building centromeres: home sweet home or a nomadic existence? Buscaino A, et al. Curr Opin Genet Dev, 2010 Apr. PMID 20206496.CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Maehara K, et al. Mol Cell Biol, 2010 May. PMID 20160010.HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Shuaib M, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080577.
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