癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CENPJ Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CENPJ.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9HC77 |
| Other Accession | NM_018451 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5D5 |
| Calculated MW | 153000 Da |
| Gene ID | 55835 |
|---|---|
| Other Names | Centromere protein J, CENP-J, Centrosomal P41-associated protein, LAG-3-associated protein, LYST-interacting protein 1, CENPJ, CPAP, LAP, LIP1 |
| Target/Specificity | CENPJ (NP_060921, 979 a.a. ~ 1088 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CENPJ Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.
REFERENCES
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. Chang J, et al. EMBO J, 2010 Jul 21. PMID 20531387.Novel CENPJ mutation causes Seckel syndrome. Al-Dosari MS, et al. J Med Genet, 2010 Jun. PMID 20522431.Sex-dependent association of common variants of microcephaly genes with brain structure. Rimol LM, et al. Proc Natl Acad Sci U S A, 2010 Jan 5. PMID 20080800.Dimerization of CPAP orchestrates centrosome cohesion plasticity. Zhao L, et al. J Biol Chem, 2010 Jan 22. PMID 19889632.CPAP is a cell-cycle regulated protein that controls centriole length. Tang CJ, et al. Nat Cell Biol, 2009 Jul. PMID 19503075.
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