癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CER1 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a full length recombinant CER1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP |
|---|---|
| Primary Accession | O95813 |
| Other Accession | NM_005454 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3E12 |
| Calculated MW | 30084 Da |
| Gene ID | 9350 |
|---|---|
| Other Names | Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4 |
| Target/Specificity | CER1 (NP_005445.1, 158 a.a. ~ 266 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CER1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
REFERENCES
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. Young RP, et al. Postgrad Med J, 2009 Oct. PMID 19789190.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Lung cancer susceptibility model based on age, family history and genetic variants. Young RP, et al. PLoS One, 2009. PMID 19390575.Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. Tang PL, et al. J Bone Miner Res, 2009 Jun. PMID 19113921.Clinical and cytogenetic characterization of 13 Dutch patients with deletion 9p syndrome: Delineation of the critical region for a consensus phenotype. Swinkels ME, et al. Am J Med Genet A, 2008 Jun 1. PMID 18452192.
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