癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CHD3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CHD3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q12873 |
| Other Accession | NM_001005273 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5.0E+12 |
| Calculated MW | 226592 Da |
| Gene ID | 1107 |
|---|---|
| Other Names | Chromodomain-helicase-DNA-binding protein 3, CHD-3, ATP-dependent helicase CHD3, Mi-2 autoantigen 240 kDa protein, Mi2-alpha, Zinc finger helicase, hZFH, CHD3 |
| Target/Specificity | CHD3 (NP_001005273, 1654 a.a. ~ 1741 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CHD3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
REFERENCES
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Wang Y, et al. Cell, 2009 Aug 21. PMID 19703393.UV radiation regulates Mi-2 through protein translation and stability. Burd CJ, et al. J Biol Chem, 2008 Dec 12. PMID 18922793.Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. Sun JM, et al. J Biol Chem, 2007 Nov 9. PMID 17827154.Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. Sillibourne JE, et al. Mol Biol Cell, 2007 Sep. PMID 17626165.The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene. Pastorcic M, et al. FEBS J, 2007 Mar. PMID 17489097.
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