癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CHMP2B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CHMP2B.
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Application 
| E |
|---|---|
| Primary Accession | Q9UQN3 |
| Other Accession | BC001553.1 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2H6-1E6 |
| Calculated MW | 23907 Da |
| Gene ID | 25978 |
|---|---|
| Other Names | Charged multivesicular body protein 2b, CHMP25, Chromatin-modifying protein 2b, CHMP2b, Vacuolar protein sorting-associated protein 2-2, Vps2-2, hVps2-2, CHMP2B |
| Target/Specificity | CHMP2B (AAH01553.1, 1 a.a. ~ 213 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CHMP2B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.
REFERENCES
CHMP2B mutations are rare in French families with frontotemporal lobar degeneration. Ghanim M, et al. J Neurol, 2010 Jul 14. PMID 20625756.FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. Tsai CP, et al. Neurobiol Aging, 2010 May 14. PMID 20472325.Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus. Yamazaki Y, et al. Neurosci Lett, 2010 Jun 21. PMID 20420883.Mutations in CHMP2B are not a cause of frontotemporal lobar degeneration in Finnish patients. Kaivorinne AL, et al. Eur J Neurol, 2010 Apr 20. PMID 20412296.Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). Cox LE, et al. PLoS One, 2010 Mar 24. PMID 20352044.
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