癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CITED1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant CITED1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q99966 |
| Other Accession | NM_004143 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5H6 |
| Calculated MW | 19896 Da |
| Gene ID | 4435 |
|---|---|
| Other Names | Cbp/p300-interacting transactivator 1, Melanocyte-specific protein 1, CITED1, MSG1 |
| Target/Specificity | CITED1 (NP_004134, 94 a.a. ~ 193 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CITED1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.
REFERENCES
An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Dillon RL, et al. Mol Cell Biol, 2007 Dec. PMID 17938205.CITED1 expression in Wilms' tumor and embryonic kidney. Lovvorn HN, et al. Neoplasia, 2007 Jul. PMID 17710162.Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1. Lovvorn HN 3rd, et al. J Pediatr Surg, 2007 Mar. PMID 17336183.The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. Shi G, et al. J Biol Chem, 2006 Sep 15. PMID 16864582.Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. Plisov S, et al. J Am Soc Nephrol, 2005 Jun. PMID 15843474.
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