癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLCN2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CLCN2.
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P51788 |
| Other Accession | BC021578 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 30 |
| Calculated MW | 98535 Da |
| Gene ID | 1181 |
|---|---|
| Other Names | Chloride channel protein 2, ClC-2, CLCN2 |
| Target/Specificity | CLCN2 (AAH21578.1, 38 a.a. ~ 387 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLCN2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts. Scheper GC, et al. Genet Test Mol Biomarkers, 2010 Apr. PMID 20187760. Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. Cornejo I, et al. J Cell Physiol, 2009 Dec. PMID 19711355. CLCN2 variants in idiopathic generalized epilepsy. Kleefuss-Lie A, et al. Nat Genet, 2009 Sep. PMID 19710712. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. Thompson CH, et al. J Biol Chem, 2009 Sep 18. PMID 19574231. PIKfyve-dependent regulation of the Cl- channel ClC-2. Klaus F, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232516.
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