癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLDN20 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CLDN20.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P56880 |
| Other Accession | BC020838 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4E7 |
| Calculated MW | 23515 Da |
| Gene ID | 49861 |
|---|---|
| Other Names | Claudin-20, CLDN20 |
| Target/Specificity | CLDN20 (AAH20838, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLDN20 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.
REFERENCES
The claudins. Lal-Nag M, et al. Genome Biol, 2009. PMID 19706201.Biology of claudins. Angelow S, et al. Am J Physiol Renal Physiol, 2008 Oct. PMID 18480174.Structure and function of claudins. Krause G, et al. Biochim Biophys Acta, 2008 Mar. PMID 18036336.Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Rizzolo LJ, et al. Mol Vis, 2007 Jul 23. PMID 17679949.The claudin gene family: expression in normal and neoplastic tissues. Hewitt KJ, et al. BMC Cancer, 2006 Jul 12. PMID 16836752.
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