癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLDN5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CLDN5.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | O00501 |
| Other Accession | NM_003277 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3D8 |
| Calculated MW | 23147 Da |
| Gene ID | 7122 |
|---|---|
| Other Names | Claudin-5, Transmembrane protein deleted in VCFS, TMDVCF, CLDN5, AWAL, TMVCF |
| Target/Specificity | CLDN5 (NP_003268, 29 a.a. ~ 81 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLDN5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
REFERENCES
Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-induced Lung Injury. Jang AS, et al. Am J Respir Cell Mol Biol, 2010 Jun 4. PMID 20525806.Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Kaarteenaho R, et al. Respir Res, 2010 May 17. PMID 20478039.A weak association of the CLDN5 locus with schizophrenia in Chinese case-control samples. Wu N, et al. Psychiatry Res, 2010 Jun 30. PMID 20452046.Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. Turunen M, et al. Anticancer Res, 2009 Dec. PMID 20044634.Claudins in human cancer: a review. Ouban A, et al. Histol Histopathol, 2010 Jan. PMID 19924644.
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