癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLU Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CLU.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P10909 |
| Other Accession | NM_001831 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A11 |
| Calculated MW | 52495 Da |
| Gene ID | 1191 |
|---|---|
| Other Names | Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Apo-J, Complement cytolysis inhibitor, CLI, Complement-associated protein SP-40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, TRPM-2, Clusterin beta chain, ApoJalpha, Complement cytolysis inhibitor a chain, Clusterin alpha chain, ApoJbeta, Complement cytolysis inhibitor b chain, CLU, APOJ, CLI, KUB1 |
| Target/Specificity | CLU (NP_001822, 402 a.a. ~ 501 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLU Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene appears to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. However, the function of this protein is unknown. Three transcript variants encoding different isoforms have been found for this gene, and one of them is secreted and processed into a mature form.
REFERENCES
Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old. Mengel-From J, et al. Neurobiol Aging, 2010 Aug 23. PMID 20739100.Association Analysis Between the rs11136000 Single Nucleotide Polymorphism in Clusterin Gene, rs3851179 Single Nucleotide Polymorphism in Clathrin Assembly Lymphoid Myeloid Protein Gene and the Patients with Schizophrenia in the Chinese Population. Zhou Y, et al. DNA Cell Biol, 2010 Aug 25. PMID 20738160.Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes. Jun G, et al. Arch Neurol, 2010 Sep 3. PMID 20697030.Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Yu JT, et al. Clin Chim Acta, 2010 Oct 9. PMID 20599866.Association of CLU and PICALM variants with Alzheimer's disease. Kamboh MI, et al. Neurobiol Aging, 2010 Jun 4. PMID 20570404.
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