癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CNOT2 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant CNOT2.
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NZN8 |
| Other Accession | NM_014515 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3F1 |
| Calculated MW | 59738 Da |
| Gene ID | 4848 |
|---|---|
| Other Names | CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2 |
| Target/Specificity | CNOT2 (NP_055330, 441 a.a. ~ 540 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CNOT2 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. Miyasaka T, et al. Cancer Sci, 2008 Apr. PMID 18377426.Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Morita M, et al. Mol Cell Biol, 2007 Jul. PMID 17452450.Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. Winkler GS, et al. EMBO J, 2006 Jul 12. PMID 16778766.Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Jayne S, et al. Biochem J, 2006 Sep 15. PMID 16712523.
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