癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CNOT3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CNOT3.
- 产品详情
- 实验流程
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O75175 |
| Other Accession | NM_014516 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4B8 |
| Calculated MW | 81872 Da |
| Gene ID | 4849 |
|---|---|
| Other Names | CCR4-NOT transcription complex subunit 3, CCR4-associated factor 3, Leukocyte receptor cluster member 2, CNOT3, KIAA0691, LENG2, NOT3 |
| Target/Specificity | CNOT3 (NP_055331, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CNOT3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.Identification of Ccr4-Not complex components as regulators of transition from partial to genuine induced pluripotent stem cells.Kamon M, Katano M, Hiraki-Kamon K, Hishida T, Nakachi Y, Mizuno Y, Okazaki Y, Suzuki A, Hirasaki M, Ueda A, Nishimoto M, Kato H, Okuda AStem Cells Dev. 2013 Nov 8.2.The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not Complex.Doidge R, Mittal S, Aslam A, Winkler GS.PLoS One. 2012;7(12):e51331. doi: 10.1371/journal.pone.0051331. Epub 2012 Dec 7.3.The Ccr4-not deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.Aslam A, Mittal S, Koch F, Andrau JC, Winkler GS.Mol Biol Cell. 2009 Sep;20(17):3840-50. Epub 2009 Jul 15.
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