癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COMMD1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant COMMD1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IP, E |
|---|---|
| Primary Accession | Q8N668 |
| Other Accession | BC022046 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2A12 |
| Calculated MW | 21178 Da |
| Gene ID | 150684 |
|---|---|
| Other Names | COMM domain-containing protein 1, Protein Murr1, COMMD1, C2orf5, MURR1 |
| Target/Specificity | COMMD1 (AAH22046.1, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | COMMD1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).
REFERENCES
1.Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1?.Schilling D, Bayer C, Li W, Molls M, Vaupel P, Multhoff G.PLoS One. 2012;7(2):e31110. Epub 2012 Feb 7.2.COMMD1-Mediated Ubiquitination Regulates CFTR Trafficking.Drevillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelievre A, Aissat A, Tarze A, Goossens M, Fanen P.PLoS One. 2011 Mar 31;6(3):e18334.3.Cu/Zn superoxide dismutase maturation and activity are regulated by COMMD1.Vonk WI, Wijmenga C, Berger R, van de Sluis B, Klomp LW.J Biol Chem. 2010 Jul 1. [Epub ahead of print]4.Copper-Induced Translocation of the Wilson Disease Protein ATP7B Independent of Murr1/COMMD1 and Rab7.Weiss KH, Lozoya JC, Tuma S, Gotthardt D, Reichert J, Ehehalt R, Stremmel W, Fullekrug J.Am J Pathol. 2008 Dec;173(6):1783-1794. Epub 2008 Oct 305.COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with PtdIns(4,5)p2.Burkhead JL, Morgan CT, Shinde U, Haddock G, Lutsenko S.J Biol Chem. 2009 Jan 2;284(1):696-707. Epub 2008 Oct 21.6.Tumor suppressor ARF promotes non-classic proteasomal independent polyubiquitination of COMMD1.Huang Y, Wu M, Li HY.J Biol Chem. 2008 Apr 25;283(17):11453-60. Epub 2008 Feb 27.7.Distinct Wilson's disease mutations in ATP7B are associated with enhanced binding to COMMD1 and reduced stability of ATP7B.de Bie P, van de Sluis B, Burstein E, van de Berghe PV, Muller P, Berger R, Gitlin JD, Wijmenga C, Klomp LW.Gastroenterology. 2007 Oct;133(4):1316-26. Epub 2007 Jul 25.8.COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.Maine GN, Mao X, Komarck CM, Burstein E.EMBO J. 2007 Jan 24;26(2):436-47. Epub 2006 Dec 21.
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