癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COPB Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant COPB.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P53618 |
| Other Accession | NM_016451 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3E11 |
| Calculated MW | 107142 Da |
| Gene ID | 1315 |
|---|---|
| Other Names | Coatomer subunit beta, Beta-coat protein, Beta-COP, COPB1, COPB |
| Target/Specificity | COPB (NP_057535, 854 a.a. ~ 953 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | COPB Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described.
REFERENCES
Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. Burman JL, et al. J Biol Chem, 2008 Aug 15. PMID 18556652.Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2. Cannavo E, et al. J Biol Chem, 2007 Feb 2. PMID 17148452.Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. Goryachev AB, et al. PLoS Comput Biol, 2006 Dec 1. PMID 17140284.Insights into COPI coat assembly and function in living cells. Lippincott-Schwartz J, et al. Trends Cell Biol, 2006 Oct. PMID 16956762.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.
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