癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRYM Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant CRYM.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IP, E |
|---|---|
| Primary Accession | Q14894 |
| Other Accession | NM_001888 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 6B3 |
| Calculated MW | 33776 Da |
| Gene ID | 1428 |
|---|---|
| Other Names | Ketimine reductase mu-crystallin, NADP-regulated thyroid-hormone-binding protein, CRYM, THBP |
| Target/Specificity | CRYM (NP_001879, 215 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IP~~N/A E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CRYM Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
REFERENCES
1.The FSHD Atrophic Myotube Phenotype Is Caused by DUX4 Expression.Vanderplanck C, Ansseau E, Charron S, Stricwant N, Tassin A, Laoudj-Chenivesse D, Wilton SD, Coppee F, Belayew A.PLoS One. 2011;6(10):e26820. Epub 2011 Oct 28.2.Proteomic Analysis Illuminates a Novel Structural Definition of the Claustrum and Insula.Mathur BN, Caprioli RM, Deutch AY.Cereb Cortex. 2009 Oct;19(10):2372-9. Epub 2009 Jan 23.3.Abnormal expression of mu-crystallin in facioscapulohumeral muscular dystrophy.Reed PW, Corse AM, Porter NC, Flanigan KM, Bloch RJ.Exp Neurol. 2007 Jun;205(2):583-6. Epub 2007 Mar 21.
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