癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CTH Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant CTH.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P32929 |
| Other Accession | BC015807 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | S51 |
| Calculated MW | 44508 Da |
| Gene ID | 1491 |
|---|---|
| Other Names | Cystathionine gamma-lyase, Cysteine-protein sulfhydrase, Gamma-cystathionase, CTH |
| Target/Specificity | CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CTH Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
REFERENCES
1.cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation.Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, Cantalupo A, Dhayade S, Karalis KP, Wang R, Feil R, Cirino G.PLoS One. 2012;7(12):e53319. doi: 10.1371/journal.pone.0053319. Epub 2012 Dec 28.2.Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes.Zhang L, Yang G, Untereiner A, Ju Y, Wu L, Wang R.Endocrinology. 2013 Jan;154(1):114-26. doi: 10.1210/en.2012-1658. Epub 2012 Nov 26.3.An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries.Streeter E, Hart J, Badoer E.Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul 17.4.Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine ?]-Synthase and Cystathionine ?^-Lyase, in Human Prostatic Tissue and Cells.Guo H, Gai JW, Wang Y, Jin HF, Du JB, Jin J.Urology. 2012 Feb;79(2):483.e1-5.5.Glucocorticoids suppress cystathionine gamma-lyase expression and H(2)S production in lipopolysaccharide-treated macrophages.Zhu XY, Liu SJ, Liu YJ, Wang S, Ni X.Cell Mol Life Sci. 2010 Jan 10. [Epub ahead of print]6.H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels.Siebert N, Cantre D, Eipel C, Vollmar B.Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1266-73. Epub 2008 Oct 30.
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