癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CUL7 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CUL7.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14999 |
| Other Accession | BC033647 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 2G11 |
| Calculated MW | 191161 Da |
| Gene ID | 9820 |
|---|---|
| Other Names | Cullin-7, CUL-7, CUL7, KIAA0076 |
| Target/Specificity | CUL7 (AAH33647, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CUL7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Gascoin-Lachambre G, et al. Placenta, 2010 Feb. PMID 20005570.A large-scale mutation search reveals genetic heterogeneity in 3M syndrome. Huber C, et al. Eur J Hum Genet, 2009 Mar. PMID 19225462.CUL7 is a novel antiapoptotic oncogene. Kim SS, et al. Cancer Res, 2007 Oct 15. PMID 17942889.Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia. Maksimova N, et al. J Med Genet, 2007 Dec. PMID 17675530.Induction of cullin 7 by DNA damage attenuates p53 function. Jung P, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17586686.
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