癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DLL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DLL1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O00548 |
| Other Accession | NM_005618 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4F8 |
| Calculated MW | 78056 Da |
| Gene ID | 28514 |
|---|---|
| Other Names | Delta-like protein 1, Drosophila Delta homolog 1, Delta1, H-Delta-1, DLL1 |
| Target/Specificity | DLL1 (NP_005609, 18 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DLL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
REFERENCES
Squamous odontogenic tumor of the mandible: a case report demonstrating immunoexpression of Notch1, 3, 4, Jagged1 and Delta1. Siar CH, et al. Eur J Med Res, 2010 Apr 8. PMID 20554499.Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Sprinzak D, et al. Nature, 2010 May 6. PMID 20418862.Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line. Qian CF, et al. Int J Mol Med, 2009 Oct. PMID 19724883.Genetic variation in healthy oldest-old. Halaschek-Wiener J, et al. PLoS One, 2009 Aug 14. PMID 19680556.Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura. Ma D, et al. Ann Hematol, 2010 Feb. PMID 19603167.
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