癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DNAI1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DNAI1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9UI46 |
| Other Accession | BC030583 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 2D10-2A5 |
| Calculated MW | 79283 Da |
| Gene ID | 27019 |
|---|---|
| Other Names | Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1 |
| Target/Specificity | DNAI1 (AAH30583, 1 a.a. ~ 699 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DNAI1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Primary ciliary dyskinesia: improving the diagnostic approach. Leigh MW, et al. Curr Opin Pediatr, 2009 Jun. PMID 19300264.Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. Zuccarello D, et al. Hum Reprod, 2008 Aug. PMID 18492703.DNAI1 mutations explain only 2% of primary ciliary dykinesia. Failly M, et al. Respiration, 2008. PMID 18434704.Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. Zariwala MA, et al. Am J Respir Crit Care Med, 2006 Oct 15. PMID 16858015.
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