癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DNMT2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DNMT2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | O14717 |
| Other Accession | BC047733 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 lambda |
| Clone Names | 1.0E+12 |
| Calculated MW | 44597 Da |
| Gene ID | 1787 |
|---|---|
| Other Names | tRNA (cytosine(38)-C(5))-methyltransferase, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2 |
| Target/Specificity | DNMT2 (AAH47733, 1 a.a. ~ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DNMT2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.
REFERENCES
Hepatitis B virus replication induces methylation of both host and viral DNA. Vivekanandan P, et al. J Virol, 2010 May. PMID 20147412.Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296.Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Schaefer M, et al. Cancer Res, 2009 Oct 15. PMID 19808971.Genetic variation in healthy oldest-old. Halaschek-Wiener J, et al. PLoS One, 2009 Aug 14. PMID 19680556.A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. El-Maarri O, et al. Hum Mol Genet, 2009 May 15. PMID 19246518.
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