癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DPYS Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DPYS.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q14117 |
| Other Accession | NM_001385 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3B1 |
| Calculated MW | 56630 Da |
| Gene ID | 1807 |
|---|---|
| Other Names | Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS |
| Target/Specificity | DPYS (NP_001376, 422 a.a. ~ 519 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DPYS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
REFERENCES
Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. Kim HY, et al. BMB Rep, 2010 Aug. PMID 20797317.Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients. van Kuilenburg AB, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20362666.Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients. Fidlerova J, et al. Cancer Chemother Pharmacol, 2010 Mar. PMID 19649633.Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2008 Jan. PMID 18216719.Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2007 Nov. PMID 18075467.
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