癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DUB3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DUB3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6R6M4 |
| Other Accession | NM_201402 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3G12 |
| Calculated MW | 59619 Da |
| Gene ID | 377630 |
|---|---|
| Other Names | Ubiquitin carboxyl-terminal hydrolase 17, USP17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, DUB-3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, USP17L2 |
| Target/Specificity | DUB3 (NP_958804, 431 a.a. ~ 530 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DUB3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.
REFERENCES
Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Pereg Y, et al. Nat Cell Biol, 2010 Apr. PMID 20228808.Personalized copy number and segmental duplication maps using next-generation sequencing. Alkan C, et al. Nat Genet, 2009 Oct. PMID 19718026.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. Burrows JF, et al. J Biol Chem, 2004 Apr 2. PMID 14699124.
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