癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
E2F8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant FLJ23311.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | A0AVK6 |
| Other Accession | BC028244 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | S1 |
| Calculated MW | 94166 Da |
| Gene ID | 79733 |
|---|---|
| Other Names | Transcription factor E2F8, E2F-8, E2F8 |
| Target/Specificity | E2F8 (AAH28244, 1 a.a. ~ 431 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | E2F8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
E2F transcription factors, such as E2F8, are essential for orchestrating expression of genes required for cell cycle progression and proliferation (Christensen et al., 2005 [PubMed 16179649]).
REFERENCES
1.E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation.Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J, Han ZG.Cancer Res. 2010 Jan 15;70(2):782-91. Epub 2010 Jan 12.2.DNA-damage response control of E2F7 and E2F8.Panagiotis Zalmas L, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB.EMBO Rep. 2008 Mar;9(3):252-9. Epub 2008 Jan 18.3.Synergistic Function of E2F7 and E2F8 Is Essential for Cell Survival and Embryonic Development.Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A.Dev Cell. 2008 Jan 15;14(1):62-75.
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