癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EGR1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant EGR1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P18146 |
| Other Accession | NM_001964 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3C7 |
| Calculated MW | 57507 Da |
| Gene ID | 1958 |
|---|---|
| Other Names | Early growth response protein 1, EGR-1, AT225, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24, EGR1, KROX24, ZNF225 |
| Target/Specificity | EGR1 (NP_001955, 444 a.a. ~ 543 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EGR1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
REFERENCES
Cigarette smoke-induced Egr-1 represses T beta R-II expression in human skin dermal fibroblasts. Kim JN, et al. Toxicology, 2010 Sep 10. PMID 20621662.Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. Xu Y, et al. J Biol Chem, 2010 Jul 23. PMID 20507991.Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells. Patel N, et al. J Biol Chem, 2010 Jul 2. PMID 20448047.Mature human neutrophils constitutively express the transcription factor EGR-1. Cullen EM, et al. Mol Immunol, 2010 May. PMID 20363028.The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. Parra E, et al. Oncol Rep, 2010 Apr. PMID 20204305.
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