癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EMILIN1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant EMILIN1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y6C2 |
| Other Accession | BC007530 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 4A3 |
| Calculated MW | 106695 Da |
| Gene ID | 11117 |
|---|---|
| Other Names | EMILIN-1, Elastin microfibril interface-located protein 1, Elastin microfibril interfacer 1, EMILIN1, EMI |
| Target/Specificity | EMILIN1 (AAH07530, 1 a.a. ~ 347 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | EMILIN1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung.
REFERENCES
Association study of the elastin microfibril interfacer 1 (EMILIN1) gene in essential hypertension. Shimodaira M, et al. Am J Hypertens, 2010 May. PMID 20186130.Emilin1 gene and essential hypertension: a two-stage association study in northern Han Chinese population. Shen C, et al. BMC Med Genet, 2009 Nov 18. PMID 19922630.NMR-based homology model for the solution structure of the C-terminal globular domain of EMILIN1. Verdone G, et al. J Biomol NMR, 2009 Feb. PMID 19023665.Candidate gene analysis in primary lymphedema. Ferrell RE, et al. Lymphat Res Biol, 2008. PMID 18564921.The solution structure of EMILIN1 globular C1q domain reveals a disordered insertion necessary for interaction with the alpha4beta1 integrin. Verdone G, et al. J Biol Chem, 2008 Jul 4. PMID 18463100.
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