癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ErbB2IP
Mouse monoclonal antibody raised against a partial recombinant ERBB2IP.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96RT1 |
| Other Accession | NM_018695 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 10G1 |
| Calculated MW | 158298 Da |
| Gene ID | 55914 |
|---|---|
| Other Names | Protein LAP2, Densin-180-like protein, Erbb2-interacting protein, Erbin, ERBB2IP, ERBIN, KIAA1225, LAP2 |
| Target/Specificity | ERBB2IP (NP_061165, 1272 a.a. ~ 1371 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | ErbB2IP is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.
REFERENCES
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Densin-180: revised membrane topology, domain structure and phosphorylation status. Thalhammer A, et al. J Neurochem, 2009 Apr. PMID 19187442.Biochemical studies and molecular dynamics simulations of Smad3-Erbin interaction identify a non-classical Erbin PDZ binding. D?liot N, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19013433.The PDZ protein erbin modulates beta-catenin-dependent transcription. Ress A, et al. Eur Surg Res, 2008. PMID 18667832.Palmitoylation of ERBIN is required for its plasma membrane localization. Izawa I, et al. Genes Cells, 2008 Jul. PMID 18498353.
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