癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBLIM1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant FBLIM1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8WUP2 |
| Other Accession | NM_017556 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3F8 |
| Calculated MW | 40670 Da |
| Gene ID | 54751 |
|---|---|
| Other Names | Filamin-binding LIM protein 1, FBLP-1, Migfilin, Mitogen-inducible 2-interacting protein, MIG2-interacting protein, FBLIM1, FBLP1 |
| Target/Specificity | FBLIM1 (NP_060026, 270 a.a. ~ 373 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FBLIM1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.
REFERENCES
Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. Zhao J, et al. J Biol Chem, 2009 Dec 4. PMID 19833732.Migfilin, a molecular switch in regulation of integrin activation. Ithychanda SS, et al. J Biol Chem, 2009 Feb 13. PMID 19074766.Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Lad Y, et al. J Biol Chem, 2008 Dec 12. PMID 18829455.Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. Lai-Cheong JE, et al. J Invest Dermatol, 2008 Sep. PMID 18528435.Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma. Papachristou DJ, et al. Histopathology, 2007 Oct. PMID 17711449.
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