癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FGF21 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a full-length recombinant FGF21.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9NSA1 |
| Other Accession | BC018404 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3A6 |
| Calculated MW | 22300 Da |
| Gene ID | 26291 |
|---|---|
| Other Names | Fibroblast growth factor 21, FGF-21, FGF21 |
| Target/Specificity | FGF21 (AAH18404, 30 a.a. ~ 209 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FGF21 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
REFERENCES
FGF21 signalling pathway and metabolic traits - genetic association analysis. Kaess BM, et al. Eur J Hum Genet, 2010 Aug 18. PMID 20717167. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Cuevas-Ramos D, et al. Eur J Endocrinol, 2010 Sep. PMID 20566587. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Dushay J, et al. Gastroenterology, 2010 Aug. PMID 20451522. Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. Wang Y, et al. J Biol Chem, 2010 May 21. PMID 20332535. Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. Fazeli PK, et al. J Clin Endocrinol Metab, 2010 Jan. PMID 19926712.
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