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FHIT Antibody (monoclonal) (M07)

Mouse monoclonal antibody raised against a partial recombinant FHIT.

     
  • 1 - FHIT Antibody (monoclonal) (M07) AT2047a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
  • 3 - FHIT Antibody (monoclonal) (M07) AT2047a
    Immunofluorescence of monoclonal antibody to FHIT on HeLa cell . [antibody concentration 10 ug/ml]
  • 10 - FHIT Antibody (monoclonal) (M07) AT2047a
    Detection limit for recombinant GST tagged FHIT is approximately 3ng/ml as a capture antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E
Primary Accession P49789
Other Accession BC032336
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG2a Kappa
Clone Names 1H2
Calculated MW 16858 Da
Additional Information
Gene ID 2272
Other Names Bis(5'-adenosyl)-triphosphatase, AP3A hydrolase, AP3Aase, Diadenosine 5', 5'''-P1, P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein, FHIT
Target/Specificity FHIT (AAH32336, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
IF~~1:50~200
E~~N/A
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFHIT Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

REFERENCES

Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. Yin DT, et al. Ann Clin Lab Sci, 2010 Summer. PMID 20689140.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.[The relationship between FHIT and WWOX expression and clinicopathological features in hepatocellular carcinoma] Lin J, et al. Zhonghua Gan Zang Bing Za Zhi, 2010 May. PMID 20510001.[Genetic and epigenetic changes of FHIT gene in patients with esophageal cancer] Tsao I, et al. Tsitol Genet, 2009 Nov-Dec. PMID 20458975.Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Okamoto R, et al. Haematologica, 2010 Sep. PMID 20435627.

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