癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FRZB Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant FRZB.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q92765 |
| Other Accession | NM_001463 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1H8 |
| Calculated MW | 36254 Da |
| Gene ID | 2487 |
|---|---|
| Other Names | Secreted frizzled-related protein 3, sFRP-3, Frezzled, Fritz, Frizzled-related protein 1, FrzB-1, FRZB, FIZ, FRE, FRP, FRZB1, SFRP3 |
| Target/Specificity | FRZB (NP_001454, 102 a.a. ~ 190 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FRZB Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
REFERENCES
Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. Zintzaras E, et al. Am J Epidemiol, 2010 Apr 15. PMID 20237151.The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Kongkham PN, et al. Oncogene, 2010 May 20. PMID 20208569.Role of secreted frizzled-related protein 3 in human renal cell carcinoma. Hirata H, et al. Cancer Res, 2010 Mar 1. PMID 20160027.Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Xu J, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080650.No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families. Gao G, et al. BMC Med Genet, 2010 Jan 1. PMID 20043861.
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