癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FUT2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant FUT2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q10981 |
| Other Accession | NM_000511 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4C12 |
| Calculated MW | 39017 Da |
| Gene ID | 2524 |
|---|---|
| Other Names | Galactoside 2-alpha-L-fucosyltransferase 2, Alpha(1, 2)FT 2, Fucosyltransferase 2, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, SE2, Secretor blood group alpha-2-fucosyltransferase, Secretor factor, Se, FUT2, SEC2 |
| Target/Specificity | FUT2 (NP_000502, 51 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | FUT2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene.
REFERENCES
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. McGovern DP, et al. Hum Mol Genet, 2010 Sep 1. PMID 20570966.Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. Cross DS, et al. BMC Genet, 2010 Jun 17. PMID 20565774.[Analysis of alpha-1,2-fucosyltransferase gene mutations in a Chinese family with para-Bombay phenotype] Xu XG, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Jun. PMID 20533259.Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes. Teresa DB, et al. Tumour Biol, 2010 Jun 1. PMID 20514537.The relationship between Lewis/Secretor genotypes and serum carbohydrate antigen 19-9 levels in a Korean population. Park HD, et al. Korean J Lab Med, 2010 Feb. PMID 20197723.
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