癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GCN5L2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant GCN5L2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF |
|---|---|
| Primary Accession | Q92830 |
| Other Accession | BC032743 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 4D3 |
| Calculated MW | 93926 Da |
| Gene ID | 2648 |
|---|---|
| Other Names | Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5 |
| Target/Specificity | GCN5L2 (AAH32743, 738 a.a. ~ 837 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GCN5L2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).
REFERENCES
GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Terreni M, et al. Retrovirology, 2010 Mar 12. PMID 20226045.Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Atanassov BS, et al. Mol Cell, 2009 Aug 14. PMID 19683498.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. Kelly TJ, et al. J Biol Chem, 2009 Jul 24. PMID 19491097.Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Paolinelli R, et al. Nat Struct Mol Biol, 2009 Apr. PMID 19343071.
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