癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GGPS1 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant GGPS1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O95749 |
| Other Accession | NM_004837 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 1C3 |
| Calculated MW | 34871 Da |
| Gene ID | 9453 |
|---|---|
| Other Names | Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, 251-, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, GGPS1 |
| Target/Specificity | GGPS1 (NP_004828, 201 a.a. ~ 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GGPS1 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
REFERENCES
Genetic polymorphism of geranylgeranyl diphosphate synthase (GGSP1) predicts bone density response to bisphosphonate therapy in Korean women. Choi HJ, et al. Yonsei Med J, 2010 Mar 1. PMID 20191015.cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase. Zhao Y, et al. Sci China C Life Sci, 2000 Dec. PMID 18726356.Human geranylgeranyl diphosphate synthase is an octamer in solution. Miyagi Y, et al. J Biochem, 2007 Sep. PMID 17646172.Farnesyl transferase inhibitor resistance probed by target mutagenesis. Raz T, et al. Blood, 2007 Sep 15. PMID 17536018.Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Ma J, et al. Atherosclerosis, 2007 Mar. PMID 16806233.
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