癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GRHPR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GRHPR.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UBQ7 |
| Other Accession | BC000605 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4E6-1F2 |
| Calculated MW | 35668 Da |
| Gene ID | 9380 |
|---|---|
| Other Names | Glyoxylate reductase/hydroxypyruvate reductase, GRHPR, GLXR |
| Target/Specificity | GRHPR (AAH00605, 1 a.a. ~ 328 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GRHPR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene.
REFERENCES
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling. Levin-Iaina N, et al. J Urol, 2009 May. PMID 19296982.A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2. Takayama T, et al. Nephrol Dial Transplant, 2007 Aug. PMID 17510093.Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. Booth MP, et al. J Mol Biol, 2006 Jun 30. PMID 16756993.The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901.Primary hyperoxaluria: from gene defects to designer drugs? Danpure CJ. Nephrol Dial Transplant, 2005 Aug. PMID 15956068.
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