癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HMGB1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant HMGB1.
- 产品详情
- 实验流程
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | P09429 |
| Other Accession | BC003378 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1D5 |
| Calculated MW | 24894 Da |
| Gene ID | 3146 |
|---|---|
| Other Names | High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1, HMG1 |
| Target/Specificity | HMGB1 (AAH03378.1, 1 a.a. ~ 215 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HMGB1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1.TLR4, IL-6, IL-18, MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6.Hirano H, Yoshioka T, Yunoue S, Fujio S, Yonezawa H, Niiro T, Habu M, Oyoshi T, Sugata S, Kamezawa T, Arimura H, Hanaya R, Tokimura H, Tokudome M, Arita K.Neuropathology. 2012 Mar 13. doi: 10.1111/j.1440-1789.2012.01310.x. [Epub ahead of print]2.Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.Kijanka G, Hector S, Kay EW, Murray F, Cummins R, Murphy D, Maccraith BD, Prehn JH, Kenny D.Gut. 2010 Jan;59(1):69-78.3.Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation.Kruger B, Krick S, Dhillon N, Lerner SM, Ames S, Bromberg JS, Lin M, Walsh L, Vella J, Fischereder M, Kramer BK, Colvin RB, Heeger PS, Murphy BT, Schroppel B.Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3390-5. Epub 2009 Feb 13.
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