癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HMOX1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HMOX1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P09601 |
| Other Accession | NM_002133 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5C6 |
| Calculated MW | 32819 Da |
| Gene ID | 3162 |
|---|---|
| Other Names | Heme oxygenase 1, HO-1, HMOX1, HO, HO1 |
| Target/Specificity | HMOX1 (ENSP00000216117, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HMOX1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
REFERENCES
GT-repeat polymorphism in the heme oxygenase-1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure. Wu MM, et al. J Biomed Sci, 2010 Aug 26. PMID 20796278.GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan. Wu MM, et al. Toxicol Appl Pharmacol, 2010 Aug 12. PMID 20708634.Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. Wang X, et al. PLoS One, 2010 Aug 3. PMID 20689807.Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis. Bao W, et al. Am J Epidemiol, 2010 Sep 15. PMID 20682519.miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. Qiu L, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20633528.
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