癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HOXB1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant HOXB1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P14653 |
| Other Accession | NM_002144 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1E3 |
| Calculated MW | 32193 Da |
| Gene ID | 3211 |
|---|---|
| Other Names | Homeobox protein Hox-B1, Homeobox protein Hox-2I, HOXB1, HOX2I |
| Target/Specificity | HOXB1 (NP_002135, 1 a.a. ~ 74 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HOXB1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.
REFERENCES
Candidate gene study of HOXB1 in autism spectrum disorder. Muscarella LA, et al. Mol Autism, 2010 May 25. PMID 20678259.Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. Pillas D, et al. PLoS Genet, 2010 Feb 26. PMID 20195514.Induction of HoxB transcription by retinoic acid requires actin polymerization. Ferrai C, et al. Mol Biol Cell, 2009 Aug. PMID 19477923.UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, et al. Nature, 2007 Oct 11. PMID 17713478.Lack of association of HOXA1 and HOXB1 variants with autism in the Indian population. Sen B, et al. Psychiatr Genet, 2007 Feb. PMID 17167333.
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