癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HOXB7 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant HOXB7.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P09629 |
| Other Accession | NM_004502 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B2 |
| Calculated MW | 24015 Da |
| Gene ID | 3217 |
|---|---|
| Other Names | Homeobox protein Hox-B7, Homeobox protein HHOC1, Homeobox protein Hox-2C, HOXB7, HOX2C |
| Target/Specificity | HOXB7 (NP_004493, 55 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HOXB7 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.
REFERENCES
Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. De Souza Setubal Destro MF, et al. Int J Oncol, 2010 Jan. PMID 19956843.Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. Novak EM, et al. Eur J Haematol, 2010 Feb 1. PMID 19878270.Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. Milanovi? D, et al. Int J Cancer, 2007 Sep 15. PMID 17514648.A role for the HOXB7 homeodomain protein in DNA repair. Rubin E, et al. Cancer Res, 2007 Feb 15. PMID 17308091.Correlation between genetic variations in Hox clusters and Hirschsprung's disease. Garcia-Barcel? MM, et al. Ann Hum Genet, 2007 Jul. PMID 17274802.
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