癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HOXB8 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HOXB8.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P17481 |
| Other Accession | NM_024016 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4F8 |
| Calculated MW | 27574 Da |
| Gene ID | 3218 |
|---|---|
| Other Names | Homeobox protein Hox-B8, Homeobox protein Hox-24, Homeobox protein Hox-2D, HOXB8, HOX2D |
| Target/Specificity | HOXB8 (NP_076921, 16 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | HOXB8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
REFERENCES
Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Williams TM, et al. Dev Biol, 2005 Jan 15. PMID 15617687.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.Complete mutation analysis panel of the 39 human HOX genes. Kosaki K, et al. Teratology, 2002 Feb. PMID 11857506.Hoxb8 is required for normal grooming behavior in mice. Greer JM, et al. Neuron, 2002 Jan 3. PMID 11779477.HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Knoepfler PS, et al. Oncogene, 2001 Sep 6. PMID 11571641.
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