癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNE4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant KCNE4.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WWG9 |
| Other Accession | BC014429 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1D7 |
| Calculated MW | 23806 Da |
| Gene ID | 23704 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily E member 4, MinK-related peptide 3, Minimum potassium ion channel-related peptide 3, Potassium channel subunit beta MiRP3, KCNE4 |
| Target/Specificity | KCNE4 (AAH14429, 1 a.a. ~ 170 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNE4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.
REFERENCES
KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating. Sol? L, et al. J Cell Sci, 2009 Oct 15. PMID 19773357.Germline genomic variants associated with childhood acute lymphoblastic leukemia. Trevi?o LR, et al. Nat Genet, 2009 Sep. PMID 19684603.KCNE4 domains required for inhibition of KCNQ1. Manderfield LJ, et al. J Physiol, 2009 Jan 15. PMID 19029186.MiRP3 acts as an accessory subunit with the BK potassium channel. Levy DI, et al. Am J Physiol Renal Physiol, 2008 Aug. PMID 18463315.KCNE4 can co-associate with the I(Ks) (KCNQ1-KCNE1) channel complex. Manderfield LJ, et al. FEBS J, 2008 Mar. PMID 18279388.
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