癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNIP2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KCNIP2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9NS61 |
| Other Accession | BC034685 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 3E8 |
| Calculated MW | 30907 Da |
| Gene ID | 30819 |
|---|---|
| Other Names | Kv channel-interacting protein 2, KChIP2, A-type potassium channel modulatory protein 2, Cardiac voltage-gated potassium channel modulatory subunit, Potassium channel-interacting protein 2, KCNIP2, KCHIP2 |
| Target/Specificity | KCNIP2 (AAH34685, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNIP2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.
REFERENCES
Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex. Cotella D, et al. Pflugers Arch, 2010 Jun. PMID 20354865.[Atrial myocytes KChIP2 mRNA expression in rheumatic heart disease patients with atrial fibrillation] Tan XQ, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2009 Jun. PMID 19927631.Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. Jerng HH, et al. J Biol Chem, 2008 Dec 19. PMID 18957440.Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. Landsberger M, et al. Am Heart J, 2008 Jul. PMID 18585502.Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells. Liu WJ, et al. Acta Pharmacol Sin, 2008 Jun. PMID 18501111.
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