癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNMB4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant KCNMB4.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q86W47 |
| Other Accession | BC050621 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G7 |
| Calculated MW | 23949 Da |
| Gene ID | 27345 |
|---|---|
| Other Names | Calcium-activated potassium channel subunit beta-4, BK channel subunit beta-4, BKbeta4, Hbeta4, Calcium-activated potassium channel, subfamily M subunit beta-4, Charybdotoxin receptor subunit beta-4, K(VCA)beta-4, Maxi K channel subunit beta-4, Slo-beta-4, KCNMB4 |
| Target/Specificity | KCNMB4 (AAH50621, 1 a.a. ~ 210 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNMB4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
REFERENCES
Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. Yang CT, et al. PLoS One, 2009 Jul 3. PMID 19578543.{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia. Lee US, et al. J Physiol, 2009 Apr 1. PMID 19204046.Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Martin GE, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18981408.Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels. Gan G, et al. J Biol Chem, 2008 Aug 29. PMID 18559348.Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Cavalleri GL, et al. Lancet Neurol, 2007 Nov. PMID 17913586.
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