癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KISS1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant KISS1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q15726 |
| Other Accession | NM_002256 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1F7 |
| Calculated MW | 14705 Da |
| Gene ID | 3814 |
|---|---|
| Other Names | Metastasis-suppressor KiSS-1, Kisspeptin-1, Metastin, Kisspeptin-54, Kisspeptin-14, Kisspeptin-13, Kisspeptin-10, KISS1 |
| Target/Specificity | KISS1 (NP_002247, 46 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KISS1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
REFERENCES
1.Menstrual cyclic change of metastin/GPR54 in endometrium.Baba T, Kang HS, Hosoe Y, Kharma B, Abiko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, Mandai M, Murphy SK, Konishi IMed Mol Morphol. 2014 Jun 8.2.Determination of KISS1, KISS1R and Kisspeptin in Fat Tissue of Normal Weight and Obese Humans and Correlations between Serum Kisspeptin and Leptin.Sitticharoon C, Boonpuan V, Mitrpant C, Churintaraphan M.Siriraj Med J 2013;65: 112-1163.Expression of KiSS-1 in Epithelial Ovarian Cancer and its Role in Metastasis.Zhu W, Gao A, Chen X, Li F, Nan J, Zhang H.Applied Mechanics and Materials Vol. 140 (2012) pp 142-1514.GPR54 is a target for suppression of metastasis in endometrial cancer.Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.Mol Cancer Ther. 2011 Jan 31. [Epub ahead of print]5.Expression of the metastasis suppressor gene KISS1 in uveal melanoma.Martins CM, Fernandes BF, Antecka E, Di Cesare S, Mansure JJ, Marshall JC, Burnier MN Jr.Eye. 2008 May;22(5):707-11. Epub 2008 Jan 25.
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