癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KLF8 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant KLF8.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O95600 |
| Other Accession | NM_007250 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E11 |
| Calculated MW | 39314 Da |
| Gene ID | 11279 |
|---|---|
| Other Names | Krueppel-like factor 8, Basic krueppel-like factor 3, Zinc finger protein 741, KLF8, BKLF3, ZNF741 |
| Target/Specificity | KLF8 (NP_009181.1, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KLF8 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
REFERENCES
Small interference RNA targeting Kr?ppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. Fu WJ, et al. J Cancer Res Clin Oncol, 2010 Aug. PMID 20182889.Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Wang X, et al. J Biol Chem, 2008 May 16. PMID 18353772.Kr?ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Wang X, et al. Cancer Res, 2007 Aug 1. PMID 17671186.Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation. Hu JH, et al. J Mol Biol, 2007 Mar 2. PMID 17224162.KLF8 transcription factor participates in oncogenic transformation. Wang X, et al. Oncogene, 2007 Jan 18. PMID 16832343.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
